Garhwal university, srinagar garhwal246 174, india semalty, et al mucoadhesive buccal films of enalapril. They may be supplied as mucoadhesive buccal tablets or as other mucoadhesive solid or semisolid preparations. Preparation of mucoadhesive patches for buccal administration. Patches also ensure more accurate dosing of the drug compared to gel and ointment. Formulation and evaluation of mucoadhesive buccal patch of. Though there is ample of work done in this field of mucoadhesive patch development but clinical usage is flimsy. Mucoadhesion involves several types of bonding mechanisms, and it is the interaction between each process that allows for the adhesive process. Mucoadhesive buccal patches of ss which bypass the hepatic metabolism and release the drug at a desired. A buccal patch for systemic administration of acyclovir in the oral cavity was developed using polymers hydroxy.
Mucoadhesive buccal patches were prepared using different grades of hydroxypropyl methylcellulose hpmc k4m and k100m and. In the present investigation, buccal films were prepared with 2 mg glimepiride twice a day to develop a sustain release formulation for treatment of type 2 diabetes. An approach to prepare buccal patches using chitosan and hpmc polymers jose, jobin, charyulu, r. He formulates the optimum patch having 2500 mg of hpmc e15. The ipc was prepared using chitosan and carboxymethylated feronia limonia fruit pulp mucilage. The prepared buccal patches were evaluated for following properties like weight uniformity, thickness, folding endurance, surface ph, swelling index, invitro residence time, tensile strength, drug content, invitro release study, stability study. Formulation and evaluation of metformin hydrochloride buccal. Mucoadhesive buccal patches formulations reported in the literature. Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon 889 swelling index the swelling index was measured using the diameter method. In the present study, the bioadhesive polymer chitosan was used for the preparation of buccal patches3,4. They can be prepared by two methods solvent casting method direct milling method 32020 31 department of pharmaceutical technology, lj institute of pharmacy, ahmedabad.
Preparation of patches buccal mucoadhesive patches were prepared using polymer or polymers blends along with the drug and a suitable solvent. Chitosan, a derivative form of chitin, is a naturally. Formulation and evaluation of buccal patches of simvastatin. Manufacture and characterization of mucoadhesive buccal films. Preparation of bisoprolol fumarate buccal patches3 the buccal patches containing bpl were prepared by solvent casting method with required modification table no. Various mucoadhesive dosage forms, including tablets, patches, disks, wafers, ointments and gels have recently been developed. The physicochemical and pharmacokinetic profiles of ss make it a suitable candidate for the preparation of a buccal adhesive drug delivery system. However, buccal patch offer greater flexibility and comfort than the other devices. The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of pantoprazole which offers an attractive route of administration for systemic drug delivery. Mucoadhesive buccal films were prepared by solvent casting. Preparation of mucoadhesive patches for buccal administration of metoprolol succinate. Design and characterization of mucoadhesive buccal patches containing cetylpyridinium chloride. The sldds is almost similar to the bdds having some more advantages than buccal drug delivery system. Permeation of ond was calculated ex vivo using porcine buccal membrane.
Aug 06, 2012 formulation and evaluation of mucoadhesive buccal patches of labetalol. Evaluation of in vitro release and mechanical properties chandra sekhar kollia, ramesh gannub, vamshi vishnu yamsanib, kishan vb and madhsudan rao yamsanib acollege of pharmacy and health sciences, mercer university, atlanta, georgia, usa30341. Ann rose augusthy 1, vipin k v 2, sarath chandran c 2, muhammed nizar av 2, and sreeraj k 3. Amongst them, buccal patches offer greater flexibility and comfort than the other forms. Formulation and evaluation of buccal patches for delivery. New insight into the fabrication of smart mucoadhesive. Formulation and preparation of mucoadhesive buccal patches of. Buccal patches are highly flexible and thus much more readily tolerated by the patient than tablets. In this study mucoadhesive buccal patches were prepared. Buccal mucoadhesive tablets 12 buccal mucoadhesive patchesgels buccal mucoadhesive tablets of lercanidipine. He used hpmc e 15 as main polymer for preparation of buccal patch using solvent casting method.
Generally factors affecting the sldds are almost similar to factors related with the bdds. From the present study carried out on simvastatin buccal patches prepared from 1%. Moreover, buccal patches provide more flexibility than other drug deliveries. The specific aim of this work was to prepare mucoadhesive patches containing tetracycline hydrochloride and carvacrol in an attempt to develop a novel oral drug delivery system for the treatment of mouth infections. Mucoadhesive buccal patches can be prepared by methods mentioned below. Formulation and evaluation of mucoadhesive buccal patches of. The bilayered patches were prepared using ethyl cellulose as a backing layer and carbopol 934 as a matrix mucoadhesive layer. Preparation of buccal mucoadhesive controlled drug delivery systems of lercanidipine hydrochloride using various mucoadhesive and rate controlling polymers either alone or in combination. The purpose of this study was to develop and optimize formulations of mucoadhesive bilayered buccal patches of sumatriptan succinate using chitosan as the base matrix. And then this route is well mucoadhesive polymers are pivotal in the development of vascularized with venous blood draining the buccal buccal delivery systems which enable retention at the mucosa reaching the heart directly via the internal jugular buccal mucosal surface so providing intimate contact vein. Mucoadhesive buccal patches and use of natural polymer in its. The major categories are wetting theory, adsorption theory, diffusion theory, electrostaticic theory, and fracture theory. Evaluation of zolmitriptan mucoadhesive buccal patches.
Buccal patches for the delivery of atenolol using sodium alginate with various hydrophilic polymers like carbopol 934 p, sodium carboxymethyl cellulose, and hydroxypropyl methylcellulose in various proportions and combinations were fabricated by solvent casting technique. Oral patches are usually laminates consisting of an impermeable backing layer and a. Preparation and evaluation of buccal patches of clotrimazole for oral candida infections. A piece of porcine buccal mucosa was glued on a support and kept in a vessel placed in a thermostatic bath at 37 c 0. Formulation and evaluation of buccal patches of simvastatin by. Preclinical evaluation of novel mucoadhesive bilayer patches for. Formulation and evaluation of buccal patches for delivery of atenolol. The use of mucoadhesive polymers in buccal drug delivery has gained a great attention. For mucoadhesive measurements, films were cut in portions of 4 cm 2 and pasted on a support, connected to the dynamometer lehrmittelban, professor dr. Mucoadhesive drug delivery system is a part of controlled delivery system. Formulation and evaluation of mucoadhesive buccal films of enalapril maleate a. The oral route is the most popular and convenient route of drug administration available. Preparation of mucoadhesive buccal patches the buccal patches were prepared by solvent casting technique.
Apr 10, 20 administering the drug via membrane located below the tongue is called sublingual ddssldds generally called floor of mouth. The use of mucoadhesive polymers in buccal drug delivery has a greater application. Mucoadhesive bilayered patches for administration of. Development of mucoadhesive patches for buccal administration of ibuprofen article in journal of controlled release 991. The solution was prepared by adding pcl to a blend of dcm and dmf. Evaluation of mucoadhesive buccal patches can perform as mention below. Effect of permeation enhancers in the mucoadhesive buccal. The three major factors in determining the requisite formulation of buccal films are mucoadhesive properties, permeation enhancement, and controlled release. Preparation and evaluation of mucoadhesive buccal films of clotrimazole for oral candida infections. Mucoadhesive buccal patches based on interpolymer complexes. Formulation and optimization of mucoadhesive buccal patches of. Buccal mucoadhesive tablets are dry placing in contact with buccal mucosa. Mucoadhesive buccal tablets are prepared by compression of mono or multi.
Various natural polymers which can be used in mucoadhesive buccal patches are chitosan, sodium alginate, tragacanth, gelatin and guar gum etc. The polymers were dissolved in casting solvent 10 ml and plasticizer 30% were incorporated then calculated amount of drug dissolved in methanol 2. Mucoadhesive patch were weighed individually x 0 and placed separately in 2% agar gel plates and incubated at 370c10c. Buccal tablets of prochlorperazine maleate 6 brief resume of the intended work 6. Development of mucoadhesive patches for buccal administration of prochlorperazine. The objective of this study was to develop mucoadhesive buccal tablets of simvastatin using. Jun 09, 2010 the buccal cavity is easily accessible for self medication, and hence it is safe and well accepted by patients, since buccal patches can be very easily administered and even removed from the application site, terminating the input of drug whenever desired. The buccal mucoadhesive films of resperidone were prepared using hpmc 47cps and hpmc 15 cps polymers by casting method. For patient compliance the patches were adhered to mucous membrane of buccal cavity two times a day and the therapeutic efficacy will be maintained for 24 h. In vitro and in vivo drug release and bioadhesion navneet verma 1,2 and pronobesh chattopadhyay 3 1college of pharmacy, iftm university, moradabad244001 u. The desired percentage of chitosan was chitosan based mucoadhesive buccal patches containing bisoprolol fumarate sarath chandran c, kv. The buccal patches were prepared by solvent casting method using chitosan.
Preparation of mucoadhesive buccal patches buccoadhesive patches were prepared by solvent casting method. Ch and carvedilol were dissolved in 2% vv glacial acetic acid solution containing ammonium acetate 5 m and pe was dissolved in distilled water. Formulation and evaluation of mucoadhesive buccal patches. Development of mucoadhesive patches for buccal administration of carvedilol. The patches were prepared by the solvent casting method.
Mucoadhesive buccal patch releasing drug in the oral cavity at a predetermined rate may present distinct advantages over traditional dosage forms, such as tablets, gels and solutions. Buccal patches films they are long, flat, thin thickness, transparent with high surface area. The reported mucoadhesive buccal patches drug delivery system are summarized here. Formulation and evaluation of mucoadhesive buccal films of. Various mucoadhesive devices, including tablets, films, patches, disks, strips, ointments and gels, have recently been developed. Chitosan based mucoadhesive buccal patches containing. Literature studies on preparation and evaluation of buccal. Development of mucoadhesive buccal patches for controlled delivery of anti diabetic drug 11 animal ethics committee1009.
Mucoadhesive preparations contain one or more active substances intended for systemic absorption through the buccal mucosa over a prolonged period of time. Formulation and evaluation of buccal patches for delivery of. Preparation of mucoadhesive oral patches containing. Mucoadhesive buccal patches of lisinopril were prepared by using solvent. Development of mucoadhesive patches for buccal administration.
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